The second-generation Titan was to be a lightly reskinned, rebadged version of the Dodge Ram, but those plans fell through with the 2008 worldwide financial crisis.[10][11][12]

Nissan unveiled the second generation Titan at the 2015 North American International Auto Show.[13] The company targeted 5 percent market share, or 100,000 annual sales in U.S.[14] Sales reached 21,880 units in 2016.[14]

The standard engine was a 5.6-liter V8 gasoline engine.[15] The engine increased in power compared to the previous model, producing 390 hp (290 kW) and 394 lb⋅ft (534 N⋅m) of torque mated to a seven-speed automatic. Additionally, through the end of 2019,[16] the second-generation Titan offered a 310-horsepower (230 kW) Cummins 5.0-liter turbodiesel V8 that produces almost 555 lb⋅ft (752 N⋅m) of torque. The engine is referred to as the ISV.